Kadar IFN-? (Fungsi TH-1 cn4+) dan IL-4 (Fungsi TH-2 CD4+) pada Penderita Artritis Lepra  

Oleh:

Hadi, Suyanto ; Triyuliati

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 44 no. 01 (Jan. 2010), page 44-48.
Topik: TH-1 CD4+ and TH-2 CD4+ lymphocyte; IFN-?; IL-4; and leprosy arthritis

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Background: It was hypothesized by some expertise that there is a negative correlation between TH-1 CD4+ function (IFN-? level) and TH-2 CD4+ function (IL-4 level) in rheumatoid arthritis and lupus pathogenesis (Leader). The correlation between IFN-? level and IL-4 level in the leprosy arthritis has never been reported. The objective of the study is to evaluate the correlate between IFN-?and IL-4 level in leprosy arthritis. Method: The correlation between IFN-? level (?g/ml) and IL-4 level (?g/ml) were analysed after stimulated with several M. leprae Ag. (10 kDa, 35 kDa, and MLSA 2 ug/ml) on the peripheral blood lymphocyte culture of leprosy arthritis patients (n=22) (RPMI 1640 sigma). The study was carried out at Hayati Laboratory Gajah Mada University. The Spearman correlation test was used in analysis. Result: There were no significant correlations between IFN-? and IL-4 level given 3 different numbers of M. leprae with r1=-0.32. r2=0.262, and r3=0.324 with p1=0.888, p2=0.238, and p3=0. 747 respectively of Spearman test on arthritis leprosy group. Conclution: There is no correlation between IFN-? and IL-4 level in leprosy arthritis patients.

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