Pain Stimulated by Electric Foot Shock to Liver and Spleen Microscopic Immunological Response Features (BALB/c Mice Experimental Study)  

Oleh:

Pudjonarko, Dwi ; Jenie, M. Naharuddin ; Sadhana, Udadi

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 44 no. 01 (Jan. 2010), page 27-32.
Topik: Pain; electric foot shock; macrophages; microabscess; hepatocytes; spleen multinucleated giant cells

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Pain affects immune system by decreasing type I-immune response that might be seen on microscopic features of liver and spleen. The objective of the study is to prove the effect of pain to immune response that confirmed by liver microabscess formation. hepatocytes destruction and spleen multinucleated giant cells of Balb/c mice suffered from pain. Method: This study adapts Laboratory Experimental and Post-Test Only Control Group Design. The samples were 12 female BALB/c mice (average weight 21.88 (SD=I.75) grams and divided into two groups. The control group (C) received no other additional treatment. The Pain (P) group received pain stimulated by Electric Foot Shock (EFS) 1-3 mA at day 12th to 21st. A II groups were intravenously injected with 1 04 live L. monocytogenes at day 21st and sacrificed at day 26th by chloroform anaesthesia. Then, liver microabscess formation, hepatocytes destruction and spleen multinucleated giant cells were counted. Data were analyzed by independent t-test (significant ijp

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