Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer in Mice through Activation of PPAR{gamma}  

Oleh:

Evans, Nicholas P. ; Misyak, Sarah A. ; Schmelz, Eva M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 140 no. 03 (Mar. 2010), page 515-521.
Topik: conjugated linoleic acid; bowel disease

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Conjugated linoleic acid (CLA) exerts a protective effect on experimental inflammatory bowel disease and shows promise as a chemopreventive agent against colorectal cancer (CRC) in mice, although the mechanisms by which it exerts its beneficial effects against malignancies in the gut are not completely understood. Mice lacking PPAR{gamma} in immune and epithelial cells and PPAR{gamma}-expressing littermates were fed either control or CLA-supplemented (1 g CLA/100 g) diets to determine the role of PPAR{gamma} in inflammation-induced CRC. To induce tumor formation and colitis, mice were treated with azoxymethane and then challenged with 2% dextran sodium sulfate, respectively. Dietary CLA ameliorated disease activity, decreased colitis, and prevented adenocarcinoma formation in the PPAR{gamma}-expressing floxed mice but not in the tissue-specific PPAR{gamma}-null mice. Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPAR{gamma}-expressing, but not in the tissue-specific, PPAR{gamma}-null mice. Colonic tumor necrosis factor-{alpha} mRNA expression was significantly suppressed in CLA-fed, PPAR{gamma}-expressing mice. This study suggests CLA ameliorates colitis and prevents tumor formation in part through a PPAR{gamma}-dependent mechanism.

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