IMMATURE TO TOTAL NEUTROPHIL (I/T) RATIO SEBAGAI PENUNJANG DIAGNOSIS SEPSIS NEONATORUM  

Oleh:

Bastiana ; Aryati ; Iriani, Yulia

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 16 no. 02 (Mar. 2010), page 73-77.
Topik: I/T Ratio; neonatal sepsis

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Early diagnosis of neonatal sepsis plays an important role in the management of patients. Blood culture, currently used as the gold standard, has several limitations such as time consuming and low positive rate. For this reason, a rapid and accurate diagnostic method is required. Manual difjerential count is a practical, inexpensive method and can support the diagnosis of bacterial infections. A shift to the left in difjerential white count with a raised immature neutrophil count has be en documented in patients with bacterial infections. This led to the use of I/T ratio as a indicator towards bacterial infections. The aim of this study is to obtain the diagnostic value of I/T ratio in diagnosing neonatal sepsis. The study was a prospective and cross-sectional. The subjects were enrolled consecutively, consisting of newborn babies (from birth to 30-days old) admitted to the Neonatal Intensive Care Unit (NICU) of the Dr. Soetomo Hospital, Surabaya. Forty and three samples, consisting of 13 sepsis samples and 30 nonsepsis as controls samples were examined. I/T ratio are a ratio between immature neutrophils against total neutrophils in blood smear preparation. For the determination of the white cell differential count, a total of 100 white cells (granulocytes) were counted. I/T ratio > 0.2 showed an abnormality that suggestan infection process occur. Blood smear evaluations were done by three (3) independent observers. The result from three (3) observers were as folIows: sensitivity and specificity of I/T ratio in the diagnosis of neonatal sepsis were 69.2%, 92.3%, 61.5% and 50%, 50%, 63.3%, respectively. Positive and negative predictive values were 37.50%, 44.44%, 42.10% and 78.94%, 93.75%, 79.16%, respectively. According to Cochran test there was no difjerence found between the 3 observers (p = 0.086). However, using Kappa test no agreement between I/T ratio and sepsis (p = 0.051) difjerences were found. from this study so far, the value in the diagnosis of neonatal sepsis the I/T ratio showed a low diagnostic.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali