ANALISIS CD4 PADA PENATALAKSANAAN PASIEN KOINFEKSI HIV-TB  

Oleh:

Kadir, Nursin Abd. ; Sennang, Nurhayana ; Hardjoeno

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 16 no. 01 (Nov. 2009), page 11-13.
Topik: HIV-TB Co-infected patients; CD4 count; continous therapy; uncontinous therapy

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The Human Immunodeficiency Virus (HIV) epidemic has increased the burden of tuberculosis (TB) among young adults, especially in populations where the prevalence of TB infection is high like Indonesia. TB is the most common opportunistic infection on HIV patients (50%) in developing countries. CD4 also known as T helper lymphocytes are coordinators of body' s immune response, and it has been declining in HIV infection and be worsened by TB infection. CD4 count are standard laboratory marker of disease progression to follow¬ up and prognosis antiretroviral therapy in HIV infection. Aims to see the value of CD4 count of HIV- TB co-infected patients before and after antituberculosis together with antiretroviral therapy. A longitudinal study was conducted by collecting secondary data from the medical record and the results of Clinical Pathology Laboratory of HIV- TB co-infected patients at Wahidin Sudirohusodo Hospital period July 2007-August 2008. Data were analyzed by Wilcoxon Signed Rank Test and Mann Whitnty Test with a = 0.05. Total samples (n) were 20 patients (14 patients with continous therapy and 6 uncontinous therapy). We found different means between CD4 count before and after Therapy. CD4 count before therapy was 71.15 ± 81.04 and after therapy was 114.95 ± 109.71 (p = 0.089) with Wilcoxon Signed Rank Test. The analyzed were continued by divided samples in continous group compared with uncontinous group therapy. The result showed the CD4 alteration in continous group was 853.8% and uncontinous group was -56.6% where p = 0.000 (Mann Whitney test). CD4 count has increased significantly in HIV-TB co-infected patients 8.5 fold from CD4 baseline with continous therapy and the uncontinous one has decreased 0.5 fold from CD4 baseline.

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