PENERIMA ASAM RETINOID a(a RETINOID ACID RECEPTOR) DI LEUKEMIA AKUT PROMYELOSITIK DENGAN BATANGAN (ROD) AUER  

Oleh:

Aman, Adi K.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 15 no. 03 (Jul. 2009), page 117-120.
Topik: APL; Auer rod; Promyelocytic leukaemia; retinoid acid receptor a

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Acute Promyelocytic Leukemia (APL) is a sub type of AML with a defined clinical course and biology that is distinct from other forms of AMI. The term M3-AML was assigned to the hyper granular promyelocytic leukaemia that is characterized by blast cells with azurophilic granules, bundies of auer rods and reniform or bilobed nucleus. Clinically, APL is related to disseminate intravascular coagulation and abnormal fibrinolysis. Cytogenetically, APL may cause translocation on the promyelocytic leukaemia (PML) gene, and chromosome 15 and with the retinoic acid receptor a(RARA) gene, on chromosome 17. The diagnosis of APL is shown by bone marrow morphologically The majority of cells in the bone marrow are abnormal, having some similarities with promyeloeytes. The malignant cells bear numerous large granules and several auer rods. Aspirates of bone marrow are also taken for cytogenesis evaluation and for detecting the translocation. A twelve years giri was admitted to the hospital with haemorrhage from the gums during 5 day after extraction of a tooth. On physical examination there is no organomegaly shown. The laboratory examination found normocytic normochromic anaemia, leucopoenia and thrombocytopenia with 15% blast cell and 5% promyelocytes with multiple auer rods. The bone marrow aspirates showed predominant of promyelocyte cells (70%) with multiple auer rods

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