KADAR PENERIMA TRANSFERIN TERLARUT (sTFR) DI PENDERITA HIV / AIDS DENGAN ANEMIA  

Oleh:

Indrati AR ; Crevel R, Van ; Sumantri R ; Wisaksana R

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 15 no. 03 (Jul. 2009), page 105-108.
Topik: Soluble Transferrin Receptor; Human Immunodeficiency Virus; Acquired Immunodeficiency Syndrome. Anemia

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Anemia is the most common hematologic abnormality associated with HIV which afjecting 60 to 80 percent of patients in the late stage of the disease. The presence of anemia is associated with increased of morbidity and mortality in patients with HIV infection. Iron deficiency, chronic infIammation and antiretroviral treatment (ACT) may cause HIV associated anemia. The differentiation of iron deficiency anemia from chronic disease anemia is a diagnostic challenge. Maybe it is helpful in soluble transferrin receptor (sTFR), the cleaving of the extra cellular domain related to transferrin receptor. Because the elevated sTFR concentration is a marker of tissue iron deficiency and increased marrow erythropoietin activity. The aim of this study was to examine the diagnostic value of soluble transferrin receptor level in anemia patients with HIV/ AIDS. The Study was the part of the IMPACT (Integrated Management for Prevention, Control and Treatment of HIV/AIDS) baseline and cohort study. The study started since September 2007 in RSUP Hasan Sadikin Bandung. There were 179 HIV / AIDS patients with anemia included in this study. Complete blood count, reticulocytes, feritin, soluble transferring receptor and hsCRP were tested in these patients. It was found that the mean of sTFR in HIV patients with anemia were 1238.42U/mL (304.5-30435). sTFR had a low correlation with MCV (r -0.174), feritin (r -0.65) and absolute reticulocyte counting (r 0.172). Feritin. had moderate and significant correlation with hsCRP (r:0.429; p 0.00). There was no significant difference of sTFR level between the patients without ART, with Zidovudin and d4T (p 0.81). There was no significance difference of sTFR concentration between the low and normal MCV level (p 0.341). sTFR can not differentiate the source of anemia in patients with HIV/AIDS. It can be concluded so far that chronic disease and inflammation as reflected by the elevated hsCRP level and use of zidovudine are the main cause of anemia.

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