Detail Detection of Cerebral Microembolic Signals by Transcranial Doppler May be A Useful Part of the Equation in Determining Stroke Risk in Patients with Antiphospholipid Antibody Syndrome   Oleh:  Brey, RL ; Carolin, MK Jenis: Article from Journal Dalam koleksi: Lupus vol. 6 no. 8 (1997), page 621-624. Topik: Detection of Cerebral Microembolic Signals Fulltext: 621.full.pdf (440.47KB) Isi artikel Nearly 15 years ago antiphospholipid antibodies (aPL) were first associated with a syndrome consisting of thrombosis in the venous and arterial circulations, thrombocytopenia and recurrent fetal loss/ The broad term aPL is used to describe antibodies detected by several different techniques. When detected using enzyme-linked immunosorbent assay (ELISA) technology, the antibodies detected are named for the negatively charged phospholipid antigen used to coat the plate. Antibodies detected in this manner are generally cross-reactive among all negatively charged phospholipids.’ It is common practice for cardiolipin to be used; thus anticardiolipin antibody (aCL) is usually the particular type of aPL referred to in the literature. When detected using phospholipid dependent coagulation testing, aPL are referred to as lupus anticoagulants (LA).~ In 1992, a new wrinkle in this syndrome arose independently in the laboratories of three different research teams.’ Apolipoprotein H (apoH), a minor natural anticoagulant protein, was recognized to be an important cofactor required for the detection of aCL and some LA. Soon researchers postulated that apoH, or an altered form of apoH in association with membrane phospholipids could be the biologically important antigen to which aPL may actually be directed.’-9 There appears to be an association between antibodies directed to apoH and thrombosis which may be even stronger than the association for either aCL or LA.10-14 Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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