Abnormalities in The Protein C Anticoagulant Pathway Detected by A Novel Assay Using Human Thrombomodulin  

Oleh:

Mohri, M. ; Sata, M. ; Gomi, K. ; Maruyama, Y. ; Osame, M. ; Maruyama, I.

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 7 (1997), page 590-596.
Topik: Thrombomodulin; Protein C; Protein S; Systemic Lupus Erythematosus; Behcet Disease
Fulltext: 590.full.pdf (636.1KB)

Isi artikel

We developed a novel assay using human thrombomodulin (TM), which detected overall abnormalities in the protein C anticoagulant pathway (PC pathway). This assay indicates the degree of inhibition of prothrombinase by TM, which is represented as the percentage of prothrombinase inhibition by 25 ng/ml of TM, termed P2 I5P (Prothrombinase Inhibition Percentage). We examined P2 I5P in plasma samples from patients with systemic lupus erythematosus (SLE) with or without lupus anticoagulant (LA), patients with Behret’s disease (BD), and patients with miscellaneous thrombotic vasculitis and compared these with the P2 I5P of plasma samples from healthy volunteers in Japan. The P2sI5P were significantly lower in SLE alone (35.5 ± 12.8%, P = 0.036) and SLE with LA (33.0 ± 13.3%, P = 0.030) and BD (33.3 ± 13.4%, P = 0.010) than those in healthy volunteers (43.5 ± 10.7%). There was no significance between healthy P2 I5P and those with miscellaneous thrombotic vasculitis (44.2±8.4%, P = 0.823). These results suggest that the abnormalities of the protein C anticoagulant pathway were present in patients with SLE(LA) and BD.

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