Association of plasma amyloid ß with risk of dementia  

Oleh:

Lambert, J. -C. ; Schraen-Maschke, S. ; Richard, F.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurology (Official Journal of The American Academy of Neurology) vol. 73 no. 11 (Sep. 2009), page 847-853.
Topik: ALZHEIMER DISEASE; BODY MASS INDEX; HIGH-DENSITY LIPOPROTEIN

Ketersediaan

Perpustakaan FK Nomor Panggil: N11.K.2009.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: Several lines of evidence indicate that a decrease in the CSF concentration of amyloid ß42 (Aß42) is a potential biomarker for incident Alzheimer disease. In contrast, studies on plasma Aß1–40 and Aß1–42 peptide levels have yielded contradictory results. Here, we explored the links between incident dementia and plasma Aß1–40 and Aß1–42 peptide concentrations in the prospective, population-based Three-City (3C) Study. We also assessed the association between plasma concentrations of truncated Aß (Aßn-40 and Aßn-42) and the risk of dementia. Methods: During a subsequent 4-year follow-up period, 257 individuals presented incident dementia from 8,414 participants, and a subcohort of 1,185 individuals without dementia was drawn as a control cohort. Plasma levels of Aß1–40, Aß1–42, Aßn-40, and Aßn-42 were measured using an xMAP-based assay technology. The association between plasma Aß peptide levels and the risk of dementia was assessed using Cox proportional hazard models. Results: Of the various Aß variables analyzed, the Aß1–42/Aß1–40 and Aßn-42/Aßn-40 ratios presented the strongest association with the risk of dementia: people with a high Aß1–42/Aß1–40 or Aßn-42/Aßn-40 ratio had a lower risk of developing dementia. These associations were restricted to individuals diagnosed at 2 years of follow-up and the Aßn-42/Aßn-40 ratio was mainly associated with the risk of mixed/vascular dementia. Conclusion: Plasma Aß peptide concentrations and Aß1–42/Aß1–40 and Aßn-42/Aßn-40 ratios may be useful markers to indicate individuals susceptible to short-term risk of dementia.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali