Motor cortex and thalamic atrophy in Unverricht–Lundborg disease  

Oleh:

Koskenkorva, P. ; Khyuppenen, J. ; Niskanen, E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurology (Official Journal of The American Academy of Neurology) vol. 73 no. 08 (Aug. 2009), page 606-611.
Topik: ANTIEPILEPTIC DRUG; GRAY MATTER; WHITE MATTER

Ketersediaan

Perpustakaan FK Nomor Panggil: N11.K.2009.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: To evaluate possible changes in the gray matter volume of patients with Unverricht–Lundborg disease (EPM1) compared with healthy controls. Methods: Thirty-four genetically verified patients with EPM1 and 30 healthy controls matched for age and sex underwent MRI (T1-, T2-, fluid-attenuated inversion recovery-, and T1-weighted 3-dimensional images). T1-weighted 3-dimensional images were analyzed with voxel-based morphometry (VBM) to compare the regional differences in gray matter volumes between patients and controls. The patients with EPM1 were also clinically evaluated for myoclonus severity using the Unified Myoclonus Rating Scale. Results: VBM analysis revealed atrophy in the bilateral primary, premotor, and supplementary motor cortex. The thalamus and precuneus were also bilaterally affected. No infratentorial changes were detected in the group analysis. Conclusion: The cortical motor areas of the brain are particularly affected in EPM1, correlating with the motor symptoms of this disease. The combination of detailed imaging with neurophysiologic evaluation may help to reveal the pathogenesis of Unverricht–Lundborg disease.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali