Efek Hepatoprotektif Kombinasi Jus Wortel dan Apel Hijau Pada Mencit Jantan Terinduksi Parasetamol  

Oleh:

Wijojo, Yosef ; Widyaningrum, Yulia

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: SIGMA: Jurnal Sains dan teknologi vol. 7 no. 2 (Jul. 2004), page 173 -181.
Topik: Paracetamol-hepatotoxicity; carrot; green apple; hepatoprotective effect

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: SS25.4 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Paracetamol is widely-used as an analgesic-antipyretic as well as a model substance in drug interaction study and in an antioxidant-effectivity test. This study was conducted to investigate the hepatoprotective effect of carrot and green apple juice combination against paracematol. The carrot-green apple juice combination inhibition effect against paracetamol-induced hepatotoxicity was evaluated using Swiss male mice. The mice were grouped and given carrot-apple juice with several combinations and dose of 15 ml/kg BW, once a day for 5 successive days. Paracetamol-hepatotoxicity was determined based on GPT-activity level by spectrophotometric method and injured liver-cell intensity by histopathology. The result showa that combinations of carrot and green apple juice with 1:2; 1:1, 1:½, and 1:¼ proportions effectively inhibit paracetamol hepatotoxicity of 70.12%, 50.70%; 26.71%, and 23.46% respectively.

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