Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia  

Oleh:

Benarroch, E. E. ; Schmeichel, A. M. ; Dugger, B. N.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurology (Official Journal of The American Academy of Neurology) vol. 73 no. 02 (Jul. 2009), page 106-112.
Topik: ALZHEIMER DISEASE; GRAY MATTER; DEMENTIA

Ketersediaan

Perpustakaan FK Nomor Panggil: N11.K.2009.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Background: Experimental studies indicate that dopaminergic neurons in the ventral periaqueductal gray matter (PAG) are involved in maintenance of wakefulness. Excessive daytime sleepiness (EDS) is a common manifestation of multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) but involvement of these neurons has not yet been explored. Methods: We sought to determine whether there is loss of dopaminergic neurons in the ventral PAG in MSA and DLB. We studied the midbrain obtained at autopsy from 12 patients (9 male, 3 female, age 61 ± 3) with neuropathologically confirmed MSA, 12 patients (11 male, 1 female, age 79 ± 4) with diagnosis of DLB and limbic or neocortical Lewy body disease, and 12 controls (7 male, 5 female, ages 67 ± 4). Fifty-micron sections were immunostained for tyrosine hydroxylase (TH) or {alpha}-synuclein and costained with thionin. Cell counts were performed every 400 µm throughout the ventral PAG using stereologic techniques. Results: Compared to the total estimated cell numbers in controls (21,488 ± 8,324 cells), there was marked loss of TH neurons in the ventral PAG in both MSA (11,727 ± 5,984; p < 0.01) and DLB (5,163 ± 1,926; p < 0.001) cases. Cell loss was more marked in DLB than in MSA. There were characteristic {alpha}-synuclein inclusions in the ventral PAG in both MSA and DLB. Conclusions: There is loss of putative wake-active ventral periaqueductal gray matter dopaminergic neurons in both multiple system atrophy and dementia with Lewy bodies, which may contribute to excessive daytime sleepiness in these conditions.

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