Detail Autologous Marrow Stem Cell Transplantation for Severe Systemic Lupus Erythematosus of Long Duration   Oleh:  Marmont, AM ; Lint, MT van ; Gualandi, F. ; Bacigalupo, A. Jenis: Article from Journal Dalam koleksi: Lupus vol. 6 no. 6 (1997), page 545-548. Topik: Systemic Lupus Erythematosus (SLE); Autologous Marrow Transplantation (ABMT) Fulltext: 545.full.pdf (327.43KB) Isi artikel A 46 year woman with severe long-lasting SLE received an autologous bone marrow transplantation utilising C+ D34 haematopoietic progenitors following a 3 log T-lymphocyte depletion. The immunosuppressive regimen (conditioning) consisted of 15mg/kg Thiotepa followed by 100 mg/kg of cyclophosphamide over 2 d. Granulocytic recovery was aided by GCSF. The post-transplant course was uneventful, and a good clinical and immunologic remission (ANA negativisation) was achieved. This is the first case of SLE having received an autologous progenitor cell transplant for the autoimmune disease by itself, unaccompanied by a haematologic condition requiring transplantation. The potential, advantages and limits of this procedure, which are currently being explored worldwide, are briefly discussed. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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