Lack of Linkage Between Anti-Nuclear Antibody or Clinical Features of Systemic Lupus Erythematosus (SLE) and TCR-A/VBeta; Loci in Families of Subjects with SLE  

Oleh:

Huang, Q. ; Morris, D. ; Dunckley, H. ; Grennan, D. ; Manolios, N.

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 6 (1997), page 527-532.
Topik: Systemic Lupus Erythematosus; Genetic Susceptibility; T-cell Antigen Receptor Genes; Linkage Analysis; Affects Sib-Pairs
Fulltext: 527.full.pdf (566.72KB)

Isi artikel

The role of the TCR-A and TCR-Vβ genes in the genetic predisposition to SLE expression and antinuclear antibody (ANA) production were examined by linkage analysis in eighteen multiplex and forty-three simplex SLE families. All subjects were Caucasian. A significantly increased prevalence of positive ANAs in first-degree relatives of SLE patients from multiplex families was noticed compared to that of simplex families. Linkage between TCR-A/Vβ genes and SLE expression and ANA production were analysed by affected sib-pair method. Results showed that the haplotypes identical by descent sharing TCR-A and TCR-Vβ genes in the affected sib-pairs was not different from that expected (P = 0.93 and P = 0.74, respectively). There was no linkage between ANA positivity and TCR-A and TCR-Vβ genes in ANA positive sib-pairs from both multiplex and simplex families. This study suggests that germline TCR-A and TCR-Vβ gene loci confer no susceptibility to ANA and SLE expression.

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