Detail CD69 to CD3 Ratio of Peripheral Blood Mononuclear Cells as A Marker to Monitor Systemic Lupus Erythematosus Disease Activity   Oleh:  Su, C-C. ; Shau, W-Y. ; Wang, C-R. ; Chuang, C-Y. ; Chen, C-Y. Jenis: Article from Journal Dalam koleksi: Lupus vol. 6 no. 5 (1997), page 449-454. Topik: CD69; CD3; Systemic Lupus Erythematosus; SLEDAI Fulltext: 449.full.pdf (472.9KB) Isi artikel CD69 is an early T cell activation marker. In order to investigate whether the disease activity of systemic lupus erythematosus (SLE) is correlated with T cell hyperactivity as well as B cell hyperactivity, we measured the CD69 to CD3 ratio (CD69/CD3) of peripheral blood mononuclear cells (PBMCs) from 42 SLE patients and 18 healthy controls. To assess B cell activation, we measured the levels of anti-dsDNA, complement C3 and C4. Disease activity was assessed with the SLE disease activity index (SLEDAI) score. The mean value (± standard deviation) of CD69/CD3 for SLE patients (3.34 ± 0.486) and healthy controls (0.92 ± 0.015) were significantly different (P < 0.05). CD69/CD3, anti-dsDNA, C3 and C4 were all significantly correlated with SLEDAI (r = 0.50, 0.51, -0.68, -0.31, respectively, P < 0.05). CD69/CD3 could explain 25.4% of the variance in SLEDAI, and 6.7% of the variance that was independent of anti-dsDNA, C3 and C4. In patients with SLEDAI scores which were discordant with anti-dsDNA, C3 and C4 values, CD69/ CD3 still showed high correlation with SLEDAI. We conclude that CD69/CD3, which detects T cell activation, is correlated with SLEDAI scores. Thus, T cell activation contributes part of the disease activity independent of B cell activity. This marker can complement in the estimation of disease activity when levels of anti-dsDNA, C3 and C4 fail to show good correlation. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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