Detail The effect of bovine lactoferrin administration on CD4+ lymphocyte count of HIV-positive patients at RSUPNCM Jakarta (dipresentasikan di dalam Pertemuan Ilmiah Perhimpunan Dokter Peduli AIDS Indonesia (PDPAI) 30 Sep - 1 Okt 2010) Bibliografi Author: Rahardja, Florentina Mariane ; Lestiani, Lanny ; Sukmana, Nanang Topik: HIV-positive; bovine lactoferrin; CD4+ lymphocyte count; JABFUNG2014 Bahasa: (EN )    ISBN: 978-979-17828-1-4     Penerbit: Pertemuan Ilmiah Perhimpunan Dokter Peduli AIDS Indonesia (PDPAI)     Tempat Terbit: Jakarta    Tahun Terbit: 2010     Jenis: Papers/Makalah - pada seminar nasional Fulltext: Lactoferrin.pdf (329.2KB; 6 download) Cover - Clinical Research Meeting 2010 - Florentina Marianne - text optim.pdf (1.24MB; 8 download) Abstract The aim of this preliminary study is to find out the effect of bovine lactoferrin administration on CD4+ lymphocyte count of adult HIV-infected patients. The study was conducted from February to April 2010, at POKDISUS AIDS Department of Internal Medicine, Central District Cipto Mangunkusumo National General Hospital (RSUPNCM) Jakarta. Subjects were selected from HIV-positive patients and only 28 were fully participated in the study. Capsules containing 200 mg of bovine lactoferrin were taken orally by all subjects once a day for six weeks. Data were collected before and after bovine lactoferrin administration by interview, anthropometric measurement, and laboratory examination of blood for determining CD4+ lymphocyte count. Daily dietary intake data were determined by using 1 x 24 hour food recall and 3 x 24 hour food record at the beginning and at the end of the study. Mean value of CD4+ lymphocyte count before lactoferrin administration was 231.85 ± 122.89 cells/gL and increased to median value of 236.50 cells/[IL (50.00-731.00 cells/µL) after six weeks intervention. Wilcoxon test on the above values showed no significant difference (p=0.22).Mean value of CD4+ lymphocyte count of untreated subjects with ARV before lactoferrin administration was 302.33 ± 132.79 cells/pL and increased to 345.33 ± 202.33 cells/µL at the end of study. The same response was also found in treated subjects with ARV where the mean value of CD4+ lymphocyte count increased from 178.00 ± 84.77 cells/µL before lactoferrin administration to 204.38 ± 122.66 cells/pL, thereafter. Paired t-test on the increased CD4+ lymphocyte count between treated and untreated subjects with ARV showed no significant difference (p=0.12). The improvement of CD4+ lymphocyte count after lactoferrin administration was seen in 7 out of 12 untreated subjects (58.33%) and in 9 out of 16 treated subjects with ARV (56.25%). Chi-Square's test showed that the improvement on both groups was not significant (p=0.91). It can be concluded that after six weeks intervention with bovine lactoferrin, mean value of CD4+ lymphocyte count of the subjects increased above baseline but statistically the changes were not significantly different. However, although statistically the difference was not significant, the increasing number of CD4+ lymphocyte count has a clinical benefit. This argument is supported by existing data that the improvement of CD4+ lymphocyte count found in 7 out of 12 untreated subjects and also in 9 out 16 subjects treated with ARV but almost two years treated, their CD4 lymphocyte count failed to increase. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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