T Cells Specific for DNA-Binding Peptides  

Oleh:

Wang, M. ; Desai, D. ; Marion, T.N.

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 3 (1997), page 349-350.
Topik: Autoimmunity; Anti-DNA; T Cells; Lupus; Mice
Fulltext: 349.full.pdf (190.07KB)

Isi artikel

Results from our laboratory as well as others have indicated that autoimmunity to DNA in lupus-prone (NZB x NZW)F1 mice has the characteristics of an antigen-driven, secondary immune response to DNA.’ 1 The progressive selection for native DNA (dsDNA) specificity as the autoimmune antibody response matures suggests that dsDNA or more likely dsDNA-protein complexes may be the immune stimulus for autoimmune DNA antibody production. In more recent experiments we have been able to confirm that complexes of DNA and a DNA-binding peptide Fusl will stimulate the production of anti- DNA antibodies in mice not genetically prone to autoimmune disease.2,3 The DNA-specific antibody induced by immunisation with DNA-Fusl complexes has serological, structural, and immunopathogenic potential of autoimmune anti-DNA antibody. The Fus 1 peptide is 27 amino acids long, highly basic, and has the structural characteristics of a ’zinc-finger’ DNA-binding motif.

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