T and B Cell Recognition of Idiotypes of Anti-DNA Autoantibodies  

Oleh:

Gavalchin, J. ; Staines, N.A.

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 3 (1997), page 337-343.
Topik: Anti-DNA Antibody; SLE; Idiotype; T Cells; Modification of Disease
Fulltext: 337.full.pdf (701.45KB)

Isi artikel

The idiotypic network hypothesis, as proposed by Jeme,’ predicts that interactions between antibodies via idiotopes (types) and between T cells and B cells via idiotype-specific receptors are critical in the regulation of the immune system. Cross-reactive idiotypes (CRI) on anti-DNA antibodies have been identified in both murine models of lupus2-5 and in human lupus,6-9 and investigations into the role of idiotypic regulation in the pathogenesis of SLE have demonstrated their importance. Immunization with an immunoglobulin light chain expressing a CRI associated with murine anti-DNA antibodies induced autoantibody production in normal mice.’° Induction of an experimental disease resembling murine SLE was achieved when normal mice were immunized with a human anti-DNA antibody carrying the 16/6 idiotype (Id).&dquo; Anti-Id antibody has been shown to modulate the production of anti-DNA antibody both in vitro’2 and in vivo’3,’a and both Id-specific CD4 + helper’s°’6 and CD8 + suppressor cells&dquo; appear to be involved.

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