T Helper Cells Driving Pathogenic Anti-DNA Autoantibody Production in Lupus : Nucleosomal Epitopes and CD40 Ligand Signals  

Oleh:

Datta, S.K. ; Kaliyaperumal, A. ; Mehta, Ami Desai

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 3 (1997), page 333-336.
Topik: Autoimmune Disease; Systemic Lupus Erythematosus; T-cell Receptors; Helper-Inducer T Cells; Co-Stimulatory Signals; Immunotherapy
Fulltext: 333.full.pdf (375.04KB)

Isi artikel

Multiple mechanisms contribute to the pathogenesis of spontaneous SLE. However, despite the presence of polyclonal T and B cell hyperactivity, autoimmunity in lupus is not global, it is directed mainly against nuclear antigens and other products of apoptosis. Autoantibodies that bind DNA play a major role in the development of lupus nephritis, yet, B cells of normal subjects produce natural anti-DNA autoantibodies. Moreover, DNA is only a target antigen and not the primary immunogen, because deliberate immunization with DNA does not lead to SLE. Extensive studies with the NZB x SWR model, as well as human SLE have simplified some of these complexities and paradoxes of lupus and are helping to define the primary immunogen(s) that drives the pathogenic autoimmune response.

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