Are DNA Antibodies Actually Pathogenic?  

Oleh:

Naparstek, Y. ; Madaio, M.P.

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 3 (1997), page 307-309.
Topik: Autoantibodies; Anti-DNA; Target Antigens; SLE; Pathogenesis
Fulltext: 307.full.pdf (314.09KB)

Isi artikel

High serum levels of anti-DNA antibodies are found almost exclusively in systemic lupus erythematosus (SLE), and the combination of a high anti-DNA with low complement levels is virtually diagnostic of lupus. But are these antibodies pathogenic and if they are what are their target antigen in vivo? Is it an intracellular antigen like DNA, a cell surface protein or an extracellular component?

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