Impact of Long-acting Calcium Channel Blockers on the Prognosis of Patients with Coronary Artery Disease With and Without Chronic Kidney Disease: a Comparison of Three Drugs  

Oleh:

Nitta, Y ; Yamamoto, R ; Yamaguchi, Y. ; Katsuda, S ; Kaku, B

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 01 (Jan. 2010), page 253-265.
Topik: coronary artery disease; hypertension; cardiovascular disease; chronic kidney disease; calcium channel blocker; benidipine; nifedipine; prognosis

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Calcium channel blockers (CCBs) can prevent cardiovascular events in patients with coronary artery disease (CAD). This study looked retrospectively at the prognosis of CAD in hypertensive patients with CAD who had undergone a coronary angiograph, had been given a CCB (benidipine [n = 66], amlodipine [n = 45], or long-acting nifedipine [n = 31]) on hospital discharge and were then followed up for a mean ± SD of 5.2 ± 2.9 years. Systolic/diastolic blood pressure for all 142 patients decreased significantly from a mean ± SD of 137 ± 20/74 ± 15 mmHg to 129 ± 20/71 ± 12 mmHg. Major adverse cardiovascular events (MACE) occurred in 15 patients. Chronic kidney disease (CKD) was a significant risk factor for MACE (hazard ratio 2.35, 95% confidence intervals 1.45, 3.80). Benidipine was superior to nifedipine in preventing MACE in patients both with and without CKD. In conclusion, benidipine and amlodipine reduced the frequency of MACE in hypertensive patients with CAD, particularly in those with complicating CKD.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali