Detail Pathology, Immunopathology, and Immunohistochemistry in Cutaneous Lupus Erythematosus   Oleh:  Bajar, KM David ; Davis, BM Jenis: Article from Journal Dalam koleksi: Lupus vol. 6 no. 2 (1997), page 145-157. Topik: Lupus Erythematosus; Cutaneous Lupus Erythematosus; Cutaneous Histopathology; Cutaneous Immunofluorescence Fulltext: 145.full.pdf (1.68MB) Isi artikel The diagnosis of cutaneous lupus erythematosus (LE) generally requires clinicopathologic correlation, necessitating routine histologic examination of lesional skin. Direct immunofluorescence (DIF) of lesional skin is an adjunctive test, which can help confirm the diagnosis of cutaneous LE. DIF is particularly helpful in situations where routine histologic findings are equivocal, and in lesions of scarring alopecia. DIF of non-lesional skin (the lupus band test, LBT) is occasionally performed in the evaluation of patients with suspected systemic lupus erythematosus (SLE). A positive LBT in non-lesional, sun protected skin may correlate with the presence of renal disease, and thus provide prognostic as well as diagnostic information. More recently, immunohistochemical techniques have been used to determine the nature of inflammatory cells in LE and to study molecules, such as intercellular adhesion molecule-I (ICAM-1) in the skin of patients with LE. These studies have provided provocative data suggesting mechanisms of skin disease in LE. In this review, we will discuss the routine histologic findings in the major subsets of cutaneous LE, the direct immunofluorescence findings in both lesional and non-lesional skin, and summarize data from immunohistochemical studies of the skin in LE. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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