Systemic Lupus Erythematosus: Clinical Expression and anti-Ro/SS-A Response in Patients With and Without Lesions of Subacute Cutaneous Lupus Erythematosus  

Oleh:

Longo, FJ López ; Monteagudo, I. ; González, CM ; Grau, R. ; Carreño, L.

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 6 no. 1 (1997), page 32-39.
Topik: Systemic Lupus Erythematosus; Subacute Cutaneous Lupus Erythematosus; Anti-snRNP Antibodies; Anti-Ro/SS-A Antibodies
Fulltext: 32.pdf (744.52KB)

Isi artikel

Patients with subacute cutaneous lupus erythematosus (SCLE) have recurrent annular and/or psoriasiphorm skin lesions, with or without systemic disease. Objective: To analyse the clinical expression and the Ro/SS-A response associated with SCLE in patients with systemic lupus erythematosus (SLE). Methods: 128 consecutive patients with SLE were studied. Anti-Ro/SS-A antibodies were detected by ELISA, (anti-60 kD Ro/SSA antibodies), immunoblotting (anti-60 kD and anti-52 kD Ro/SS-A antibodies) and counterimmunoelectrophoresis (CIE). Results: Seventeen patients (13.2%) showed SCLE lesions. Photosensitivity was more frequent in patients with SCLE (82%) than in patients without these cutaneous lesions (45%) (OR: 5.6). Arthritis (OR: 6.3), Raynaud’s phenomenon (OR: 4.9), pleuritis (OR: 7.6), central nervous system disorder (OR: 6.4), renal disease (OR: 6.3), anemia (OR: 7.9), hypocomplementemia (OR: 6.1) and anti-dsDNA antibodies (OR: 12.7) were significantly more frequent in patients without SCLE. Anti- Ro/SS-A antibodies were detected in 15 (88.2%) patients with SCLE and 62 (55.8%) patients without SCLE by ELISA, in 10 (58.8%) and 34 (30.6%) patients by immunoblotting, and in 13 (76.4%) and 34 (30.6%) by CIE, respectively. Anti-60 kD-Ro/SS-A and anti-La antibodies, but not anti-52 kD-Ro/SS-A, were significantly more frequent in patients with SCLE than in patients without SCLE. Conclusions: The presence of SCLE lesions in patients with SLE is associated with a more favourable

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali