Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449  

Oleh:

Rudin, Charles M. ; Hann, Christine L. ; Laterra, John ; Yauch, Robert L. ; Callahan, Christopher A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 12 (Sep. 2009), page 1173-1178.
Topik: Medulloblastoma; Inhibitor GDC-0449

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is strongly implicated in the development of some cases of medulloblastoma. A 26-year-old man with metastatic medulloblastoma that was refractory to multiple therapies was treated with a novel hedgehog pathway inhibitor, GDC-0449; treatment resulted in rapid (although transient) regression of the tumor and reduction of symptoms. Molecular analyses of tumor specimens obtained before treatment suggested that there was activation of the hedgehog pathway, with loss of heterozygosity and somatic mutation of the gene encoding patched homologue 1 (PTCH1), a key negative regulator of hedgehog signaling.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali