Dual Inhibitory and Stimulatory Activities in Serum from SLE Patients and Lupus Mice that Regulate the Proliferation of An IL-2-Dependent T Cell Line  

Oleh:

Huang, F-P ; Stott, DI

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 4 no. 4 (1995), page 297-303.
Topik: IL-2; CTLL; Inhibitory Factor; Stimulatory Factor
Fulltext: Lupus-1995-Huang-297-303.pdf (709.84KB)

Isi artikel

In serum and plasma from SLE patients, we have detected elevated levels of factors which regulate proliferative responses of CTLL cells to IL-2. Serum samples containing these factors have dosedependent dual inhibitory and stimulatory activities on the proliferation of this IL-2-dependent T lymphocyte cell line. At high concentrations, the serum factors inhibit the proliferative responses of CTLL cells to IL-2. At low concentrations, they synergise with IL-2 stimulating the growth of cells. Similar inhibitory activity, but with lower titre, was also found to be elevated in sera of some MRL/ lpr mice, an animal model of SLE. Functional characterisation of the serum factors shows that: (1) the inhibitory activity cannot be neutralised by exogenous IL-2; (2) the stimulatory activity is not due to the presence of serum IL-2 but synergy of the factor with IL-2; (3) the factors bind directly to CTLL cells but they do not bind to protein A; and (4) the serum factors are not dialysable but heat labile. The possible pathological implications of the serum factors, particularly for the defective T cell functions in lupus disease, are discussed.

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