Relation between stable isotope ratios in human red blood cells and hair: implications for using the nitrogen isotope ratio of hair as a biomarker of eicosapentaenoic acid and docosahexaenoic acid  

Oleh:

Nash, Sarah H ; Kristal, Alan R

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 90 no. 6 (Dec. 2009), page 1642-1647.
Topik: HEALTH AND NUTRITION; nutritional epidemiology; public health

Isi artikel

Background: The nitrogen isotope ratio (expressed as {delta}15N) of red blood cells (RBCs) is highly correlated with the RBC long-chain {omega}–3 (n–3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in Yup'ik Eskimos. Because {delta}15N can also be measured in hair samples, it could provide a noninvasive, retrospective biomarker for EPA and DHA intakes. Objectives: We investigated the agreement between {delta}15N in hair and RBCs and then evaluated the relations between hair {delta}15N and RBC EPA and DHA. We also assessed the agreement in carbon isotope ratios ({delta}13C) between hair and RBCs, because {delta}13C has been proposed as a dietary biomarker in other populations. Design: We assessed relations between hair and RBC {delta}15N and {delta}13C in a community-based sample of 144 Yup'ik Eskimos and examined the correlations between {delta}15N and RBC EPA and DHA in a subset of these participants (n = 44). Results: We showed a 1:1 relation with good agreement between hair and RBC {delta}15N (r = 0.91) and {delta}13C (r = 0.87). Hair isotope ratios were greater than RBC ratios by 1.5{per thousand} for {delta}15N and by 2.3{per thousand} for {delta}13C. There were strong correlations between hair {delta}15N and RBC EPA and DHA (r = 0.83 and 0.84, respectively). Conclusions: These results support the use of hair {delta}15N values as a biomarker of EPA and DHA intakes. Because hair collection is noninvasive and the samples require no special processing, studies of EPA and DHA intakes in large populations could use biomarkers rather than self-reports to assess these fatty acids.

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