Detail Familial Systemic Lupus Erythematosus: Analysis of Extended Haplotypes of Major Histocompatibility Complex Antigens   Oleh:  Oguchi, H. ; Hashimoto, T. ; Hirohata, S. Jenis: Article from Journal Dalam koleksi: Lupus vol. 4 no. 3 (1995), page 243-244. Topik: Haplotypes Antigens Fulltext: Lupus-1995-Oguchi-243-8.pdf (375.7KB) Isi artikel It has been appreciated that genetic factors play an important role in the development and expression of human systemic lupus erythematosus (SLE)I. Thus, 7-12% of patients with SLE are supposed to have a first or second degree relative with the same disease 1,2 . The association of SLE with several allotypes of the major histocompatibility complex (MHC) class II molecules have been implicated 3 In the Japanese population, for example, HLA-DR2 and DQ3 have been shown to be increased in patients with SLE 4 . Nevertheless, no family studies have ever shown any formal genetic linkage between SLE and the MHC4. In the present report, we describe a family, in which two siblings developed SLE, with detailed analysis of MHC class II antigen genotypes and expression of autoantibodies. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved