Detail Characterization of Autoimmune Thyroiditis in MRL-lpr/lpr Mice   Oleh:  Green, LM ; Labue, M ; Lazarus, JP ; Colburn, KK Jenis: Article from Journal Dalam koleksi: Lupus vol. 4 no. 3 (1995), page 187-196. Topik: MRL-lpr/lpr Mice; Autoimmune Thyroiditis; Thyroperoxidase Fulltext: Lupus-1995-Green-187-96.pdf (1.14MB) Isi artikel MRL-lpr/lpr mice are genetically predisposed to develop a systemic lupus erythematosus-like syndrome that is clinically very similar to the human disease. The results presented here demonstrate, for the first time to our knowledge, that MRL-lpr/lpr mice also develop thyroiditis as part of their systemic autoimmune disorder. The thyroid gland was infiltrated by immunocomponent cells with defined lymphoid follicular centers and extensive interstitial lymphocytes dispersed throughout the thyroid epithelium. All the diseased mice were hypothyroid with reduced, relative levels of thyroid hormone (free T4) and elevated levels of thyroid-stimulating hormone (TSH). They also had high concentrations of circulating IgG class autoantibodies directed against thyroglobulin, thyroperoxidase and double-stranded DNA. The MRL-+/+ age-matched allelic counterpart mice had relatively few lymphocytes in their thyroid tissue, and normal levels of thyroxine and TSH. The nondiseased mice also had undetectable levels of thyroid reactive autoantibodies tested for by enzymelinked immunosorbent assays. Collectively these findings document that the MRL-lpr/lpr mice spontaneously develop autoimmune thyroiditis and can be used as a model for the study of thyroidspecific autoimmunity. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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