Detail Lack of Relationship Between Human Immunodeficiency Virus Infection and Systemic Lupus Erythematosus   Oleh:  Font, Josep ; Vidal, Josep ; Cervera, Ricard ; Soto, Alfons Lopez ; Miret, Carles ; Jimenez de Anta, Maria Teresa ; Ingelmo, Miguel Jenis: Article from Journal Dalam koleksi: Lupus vol. 4 no. 1 (1995), page 47-49. Topik: Systemic Lupus Erythematosus Human Immunodeficiency Virus Immunoblot Fulltext: 47.full.pdf (301.38KB) Isi artikel The objective of this work was to determine whether HIV-1 and HIV-2 could be involved in the pathogenesis of systemic lupus erythematosus (SLE). Seventy-five consecutive Caucasian patients with SLE presenting at one institution over a 2-year period were studied. Serum samples were surveyed for anti-HIV-1 antibodies by a commercial ELISA coated with HIV-1-p24. For confirmation, conventional immunoblots were performed with the following antigens: HIV-1-gp41, p31, p24 and p17 (recombinant) and HIV-2-gp36 (synthetic peptide). Additionally, Western blots with HIV-1-gp160, gp120, gp41, p65, p51, p24 and p18 bands were applied. Seventeen (23%) patients exhibited reactivity with HIV-1-p24 in the ELISA, but in the immunoblots and Western blots these sera samples were negative. Patients with SLE may exhibit a reactivity with HIV-1-p24 in the ELISA for HIV infection screening but not in the confirmatory blots. This false-positive reactivity is probably due to molecular mimicry between autoantigens and retroviruses or a contaminant or artefacts in the antigen preparation procedure. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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