Detail Peranan Epigallokatekin-3-Gallat (EGCG) pada teh hijau sebagai terapi adjuvan bagi kanker payudara dengan reseptor estrogen (RE) negatif (studi kepustakaan) Bibliografi Author: ANTONI, IRENE ; Margaret, Ayly (Advisor); Hidayat, Jenny (Advisor); Lembar, Stefanus (Examiner) Topik: BREAST CANCER; egcg; nnegative estrogen receptor breast cancer; serm; flavonoid; tamoxifen; green tea EGCG; negative ekstrogen receptor breast cancer; serm; flavonoid tamoxifen; green tea Bahasa: (ID )     Penerbit: Fakultas Kedokteran Unika Atma Jaya     Tempat Terbit: Jakarta Utara    Tahun Terbit: 2014     Jenis: Theses - Karya Tulis Ilmiah Kedokteran (KTI-FK) Fulltext: Irene_Antoni_KTI_2014.pdf (794.04KB; 1 download) Ketersediaan Perpustakaan FK Nomor Panggil: KTI-FK-512 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Abstract Background: Female breast cancer comes second in Southeast Asia and represent 16% of all cancers. Breast cancer incidence been multiplying, although there’re no maximal effect of therapy found yet. Cancer’s treatment needs to be combined with EGCG consumption. EGCG is a green tea compound and known as adjuvant therapy for breast cancer. Purpose: The purpose of this study is to gather information about EGCG’s work mechanism and recommended dose as adjuvant therapy for breast cancer. Methods: Systematic review were used and using Springerlink, Google scholar, and proquest. The journals were from 2003 – 2013 and key words were EGCG, negative estrogen receptor breast cancer, SERM, flavonoid, tamoxifen, green tea. Critical appraisal used to check the quality of journals. Results : 6 journals showed positive association between EGCG and breast cancer. EGCG’s roles are inducting re-expression of ER by histone modification, DNA methylation, inducting apoptosis and inhibiting cancer cell proliferation. Combination 10 µM EGCG with 100 ng/mL TSA and 20 µg/mL EGCG, 5 µM SFN and 2 µM 5-aza optimalized EGCG’s function. Conclusion: EGCG a role as adjuvant therapy for negative estrogen receptor breast cancer by regulating epigenetic mechanism. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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