Autoantibody Profile in African-American Patients with Lupus Nephritis  

Oleh:

Garcia, CO ; Molina, JF ; Urena, S Gutieterrez ; Scopelitis, E ; Wilson, WA ; Gharavi, AE

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 5 no. 6 (1996), page 602-605.
Topik: African-American; Autoantibody Profile; Ethnicity; Lupus Nephritis; Systemic Lupus Erythematosus
Fulltext: 602.full.pdf (354.62KB)

Isi artikel

Lupus nephritis (LN) is one of the major risk factors for morbidity and overall mortality in systemic lupus erythematosus (SLE). Its pathogenesis is multifactorial, and a number of risk factors, including serological markers, have been identified in recent years, correlating with clinical course and disease severity. Furthermore, a distinctive autoantibody profile has recently been reported in African- American SLE women with LN. The aim of this study was to characterize the autoantibody profile in 222 African-American SLE patients, 94 with LN and 128 without. Only anti-dsDNA achieved statistical significance between the two groups (P < 0.05). Fourteen (14.9%) patients with LN and 15 (11.7%) without it exhibited positive anti-Ro/SS-A, anti-Sm, and anti-nRNP, but without anti-La/SSB (P > 0.6). We conclude that African-American SLE patients with LN do not exhibit a specific or distinctive autoantibody profile. However, our data confirm the value of anti-dsDNA in SLE patients with LN.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali