FActor V:Q 506 Mutation and Anticardiolipin Antibodies in Systemic Lupus Erythematosus  

Oleh:

Bengtsson, A ; Zoller, B ; Frutos, PG de ; Dahlback, B ; Sturfelt, G

Jenis: Article from Journal
Dalam koleksi: Lupus vol. 5 no. 6 (1996), page 598-601.
Topik: Factor V; SLE; APC-Resistance; Thrombosis; aCL
Fulltext: 598.full.pdf (453.34KB)

Isi artikel

Inherited resistance to activated protein C (APC resistance) is an important risk factor of venous thrombosis. It is caused by a point mutation in the gene coding for coagulation factor V, called F5.V0:6Q Arterio-venous thrombosis is a common and serious medical problem in patients with systemic lupus erythematosus (SLE). We studied the prevalence of the factor V mutation associated with APC resistance and IgG anticardiolipin antibodies (aCLs) in an epidemiological cohort of 78 Swedish SLE patients, to determine their roles as risk factors for thrombosis. In addition, a detailed evaluation of the clinical manifestations in these patients was performed. Totally, 19 (24%) of the 78 SLE patients had thrombosis, 11 (14%) had venous thrombosis and 8 (10%) had a cerebral infarction caused by occlusion of cerebral vessels. Twenty-six (33%) SLE patients were aCL positive and 8 (10%) were heterozygous for the factor V mutation. Only one of the patients with venous thrombosis and one of the patients with cerebral thrombosis had the F5 V0:6Q mutation, whereas 3 patients with venous thrombosis and 5 patients with cerebral infarction were aCL positive. Eleven of 19 patients with heart valve disease were aCL positive, a statistically significant association (P = 0.01). In conclusion, we found no statistically significant association between venous thrombosis and F5 V0:6Q mutation or venous thrombosis and aCL positivity. There was, however, an association between heart valve disease and aCL positivity.

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