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Case Report Late Development of Anti-La/SS-B Antibodies in A Patient with Sjogren’s Syndrome and High Titer Anti-Ro/SS-A Antibodies
Oleh:
Satoh, M
;
Hamilton, KJ
;
Langdon, JJ
;
Akizuki, M.
;
Nakayama, S
;
Reeves, WH
;
Homma, M
Jenis:
Article from Journal
Dalam koleksi:
Lupus vol. 5 no. 3 (1996)
,
page 337-339.
Topik:
Anti-La Antibodies
;
Anti-Ro Antibodies
;
Sjogren’s Syndrome
;
Antinuclear Antibodies
Fulltext:
337.full.pdf
(278.23KB)
Isi artikel
The frequent coexistence of anti-Ro and anti-La autoantibodies is well described, however, there is little evidence of sequential development of these two autoantibodies. We report a case of typical Sjogren’s syndrome with high titer anti-Ro antibodies, who subsequently developed anti-La antibodies later in the course. This case suggests that the anti-La antibodies may actually follow the anti-Ro antibodies in some cases as hypothesized in the concept of linked set of autoantibodies, analogous to development of anti-Sm in certain anti-nRNP antibody positive SLE patients and animal models.
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