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Long Term Follow-Up of Children with Mixed Connective Tissue Disease
Oleh:
Mier, R
;
Ansell, B
;
Hall, MA
;
Hasson, N
;
Levinson, J
;
Lovell, D
;
Passo, M
;
Rennebohm, R
;
Woo, P
Jenis:
Article from Journal
Dalam koleksi:
Lupus vol. 5 no. 3 (1996)
,
page 221-226.
Topik:
Mixed Connective Tissue Disease
;
Overlap Syndrome
;
Undifferentiated Connective Tissue Disease
;
RNP Antibodies
Fulltext:
221.full.pdf
(513.67KB)
Isi artikel
Mixed connective tissue disease (MCTD) is characterized by features of more than one of the rheumatic disorders with antinuclear antibodies in a speckled pattern and with antibodies to nuclear ribonucleoprotein (nRNP). MCTD is uncommon in children and longterm follow-up studies in children are infrequently reported. A retrospective review of clinical experience at five pediatric rheumatology centers provided 11 patients who met the following inclusion criteria: (1) Kasukawa’s criteria for M1;CTD (2) presentation younger than 18th birthday; (3) greater than five years of follow-up; (4) completion of data collection form. The widely varying outcomes of these 11 children with MCTD on long-term follow-up may lend doubt that this is a unique and distinctive rheumatologic disorder.
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