Detail Respiratory Function in Systemic Lupus Erythematosus: Relation with Activity and Severity   Oleh:  Rolla, G ; Brussino, L ; Bertero, MT ; Bucca, C ; Converso, M ; Cappio, F. Caligaris Jenis: Article from Journal Dalam koleksi: Lupus vol. 5 no. 1B (1996), page 38-43. Topik: Airway Hyper-Responsiveness; Respiratory Function Fulltext: 38.full.pdf (560.32KB) Isi artikel The objective of this study was to examine the relation between respiratory function tests, disease activity and disease severity in ambulatory patients with systemic lupus erythematosus (SLE) who did not present with overt respiratory problems. Lung volumes, maximal expiratory flows at 50% and 25% of vital capacity (5 ME0F and M2)E5,F bronchial threshold to methacholine (1F1)PE5,DV transfer factor CO (KCO) were measured in 24 consecutive SLE outpatients (22 women, age 41 ± 14.8 years) and in 24 healthy controls matched for age and sex. In SLE patients alveolar-arterial oxygen gradient (2)AaO was also measured. Disease activity was assessed by European Consensus Lupus Activity Measurement (ECLAM) scoring system and disease severity by Lupus Severity of Disease Index. In comparison to controls SLE patients showed a significant decrease of total lung capacity (TLC) (91.7 ± 16.5 vs 102.7 ± 12.9% predicted, P < 0.01), M2 E5F (58.4 ± 25.2 vs 73.5 ± 19.5% predicted, P < 0.005), PF11 ED5V(2164 ± 1v12s2 4230 ± 1014 μg methacholine, P < 0.0001) and KCO (77.1 ± 20.5 vs 96.3 ± 12.4% predicted, P < 0.001). A2 aO (mean value 13.2 ± 8.4) was abnormally high (>20 mm Hg) in 12 patients. The ECLAM score of activity was inversely related with KCO (r = 0.48, P < 0.02). The severity index was significantly related with F1/EVVC ratio (r = 0.43, P < 0.05), M5 E0F (r = 0.51, P < 0.01), M2 E5F (r = 0.40, P < 0.05) and PF1 1ED5V (r = 0.51, P < 0.01). In eight patients, evaluated also after treatment intensification, there was a significant increase in KCO (from 71.8 ± 24.7 to 84.9 ± 22.3% predicted, P < 0.01) along with a decrease in ECLAM score (from 3.0 ± 1.34 to 0.69 ± 0.75, P < 0.01). The relation between disease activity and KCO suggests a relation between systemic and alveolar inflammation whereas the relation between severity index, airway patency and reactivity indices suggests a cumulative damage to the airways in SLE patients, even in the absence of overt respiratory manifestations. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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