Detail Fluctuations of Antibody to Ribosomal P Proteins Correlate With Appearance and Remission of Nephritis in SLE   Oleh:  Martin, AL ; Reichlin, Massimo Jenis: Article from Journal Dalam koleksi: Lupus vol. 5 no. 1B (1996), page 22-29. Topik: Anti-Ribosomal P; Nephritis Fulltext: 22.full.pdf (1,012.49KB) Isi artikel Antibodies to ribosomal P proteins are found in widely variable proportions (up to 42%) of patients with SLE depending on the ethnic background of the patient population. Neuropsychiatric disease was first recognized to have increased prevalence with anti-P and more recently liver and renal disease. We describe four patients with SLE and circumscribed episodes of nephritis of relatively short duration. In two patients, antibodies to ribosomal P protein were the only specificity detected at the time of appearance of active nephritis; and in the other two patients, the appearance and disappearance of anti-ribosomal P was simultaneously found with similar fluctuations in antidsDNA titers. Anti-ribosomal P antibodies were measured by Western blot and a P peptide-specific ELISA. These data raise the possibility for a pathogenic role for anti-ribosomal P antibodies in lupus nephritis. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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