Effects of fetal exposure to carbon nanoparticles on reproductive function in male offspring  

Oleh:

Yoshida, Seiichi ; Hiyoshi, Kyoko ; Oshio, Shigeru ; Takano, Hirohisa ; Takeda, Kensaku ; Ichinose, Takamichi

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 05 (Mar. 2010), page 1695-1699.
Topik: Male reproduction; daily sperm production; in utero exposure; nanoparticle

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To investigate the effects of fetal nanoparticle exposure on reproductive function in male mice offspring. Design Animal study. Setting Academic research laboratory. Animal(s) Forty pregnant ICR mice and 120 male offspring. Intervention(s) Two hundred µg of 14-nm carbon nanoparticles was administered intratracheally on days 7 and 14 of gestation, and reproductive function of male offspring was determined at ages 5, 10, and 15 weeks after birth. Main Outcome Measure(s) Maternal and fetal growth, histologic changes in the testes, and daily sperm production (DSP). Result(s) Histologic examination showed partial vacuolation of seminiferous tubules. and cellular adhesion of seminiferous epithelia was reduced at all three ages. In addition, DSP was significantly decreased in fetal carbon nanoparticle–exposed mice. The DSP in the fetal carbon nanoparticle–exposed mice decreased by 47% at the age of 5 weeks, by 34% at the age of 10 weeks, and by 32% at the age of 15 weeks. On the other hand, nanoparticle administration had no marked effect on body weight, testicle weight, epididymis weight, or serum testosterone concentration. Conclusion(s) These findings suggest that fetal nanoparticle exposure affects the reproductive function of male offspring. In the future, it would be necessary to clarify the onset mechanisms of nanoparticle-induced male reproductive disorders.

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