Detail Anti-Malarial Drugs: Possible Mechanisms of Action in Autoimmune Disease and Prospects for Drug Development   Oleh:  Fox, R Jenis: Article from Journal Dalam koleksi: Lupus vol. 5 no. 1 (1996), page 2-8. Topik: Anti-Malarial; Chloroquine; Hydroxychloroquine Fulltext: S4.full.pdf (674.27KB) Isi artikel A wide variety of mechanisms of anti-rheumatic action have been proposed for antimalarial agents. The molecular actions of chloroquine have been most thoroughly studied in vitro ainnd vivo, but it is likely that hydroxychloroquine works by a similar mechanism. Both agents are weak diprotic bases that can pass through the lipid cell membrane and preferentially concentrate in acidic cyto-plasmic vesicles. The resulting slight elevation of pH within these vesicles in macrophages or other antigen-presenting cells may influence the immune response to autoantigens. We hypothesize that anti-malarial agents influence the association of autoantigenic peptides with class II MHC molecules in the compartment for peptide loading and/or the subsequent processing and transport of the peptide-MHC complex to the cell membrane. This model of anti-malarial action provides a method to test additional drugs for their ability to modulate the immune response. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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