15-Epi-lipoxin A4 inhibits the progression of endometriosis in a murine model  

Oleh:

Qiong-Hua, Chen ; Wei-Dong, Zhou ; De-Min, Pu ; Qian-Sheng, Huang ; Tian, Li ; Qing-Xi, Chen

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 05 (Mar. 2010), page 1440-1447.
Topik: Endometriosis; Murine model; LXA4; MMP-2; MMP-9

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To examine the pro-resolution actions of 15-epi-lipoxin A4 (LXA4) on endometriotic lesions, on the concentrations and activities of matrix metalloproteinases (MMP-2 and MMP-9) in murine endometriosis. Design Prospective, vehicle-controlled experimental study. Setting Animal research facility. Animal(s) BALB/c mice. Intervention(s) Endometriosis (EM) was induced in 30 mice. Fifteen of them were administered LXA4 for 24 days (LXA4 group), whereas the other 15 served as a control group (EM group). Another 15 sham-operated mice (sham-operated group) were treated with vehicles. Main Outcome Measure(s) The weight of the endometriotic lesions was measured. The concentrations, mRNA, and activities of MMP-2 and MMP-9 were determined by enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and gelatin zymography, respectively. Result(s) Compared with EM group, the weight of the endometriotic lesions was decreased, the concentrations of MMP-2 and MMP-9 dropped, the mRNA levels of MMP-2 and MMP-9 in the peritoneal fluid cells and the endometriotic lesions were reduced, and the activities of MMP-2 and MMP-9 were inhibited in the LXA4 group. Conclusion(s) LXA4 may inhibit the progression of endometriosis possibly by lowering the concentrations and the activities of MMP-2 and MMP-9.

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