Transforming Growth Factor-ß1 and Incident Type 2 Diabetes  

Oleh:

Herder, Christian ; Zierer, Astrid ; Koenig, Wolfgang ; Roden, Michael ; Meisinger, Christa

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 32 no. 10 (Oct. 2009), page 1921-1923 .

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE Subclinical inflammation leads to insulin resistance and ß-cell dysfunction. This study aimed to assess whether levels of circulating transforming growth factor-ß1 (TGF-ß1)—a central, mainly immunosuppressive, and anti-inflammatory cytokine—were associated with incident type 2 diabetes. RESEARCH DESIGN AND METHODS We measured serum levels of TGF-ß1 from 460 individuals with and 1,474 individuals without incident type 2 diabetes in a prospective case-cohort study within the population-based MONICA (MONItoring of Trends and Determinants in CArdiovascular Disease)/KORA (Cooperative Health Research in the Region of Augsburg) cohort. RESULTS Elevated TGF-ß1 concentrations were associated with higher, not lower, risk for type 2 diabetes (age-, sex-, and survey-adjusted hazard ratios [95% CI] for increasing TGF-ß1 tertiles: 1.0, 1.08 [0.83–1.42], and 1.41 [1.08–1.83]; Pfortrend = 0.012). Adjustment for BMI and metabolic and lifestyle factors had virtually no impact on the effect size. CONCLUSIONS Elevated serum concentrations of the cytokine TGF-ß1 indicate an increased risk for type 2 diabetes. TGF-ß1 may be upregulated to counterbalance metabolic and immunological disturbances preceding type 2 diabetes.

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