Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women  

Oleh:

DiPietro, Loretta ; Dziura, James ; Yeckel, Catherine W.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 33 no. 01 (Jan. 2010), page 165-167.
Topik: DIABETES; DIABETES MELLITUS; abdominal obesity; hepatic insulin resistance; glycemic responses

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE : To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS : We studied 23 healthy older women (60–88 years old). Abdominal obesity was defined by an abdominal circumference =95 cm. Plasma glucose and insulin were measured in response to a 3-h oral glucose tolerance test. Insulin suppression of hepatic glucose production was determined using in vivo clamp techniques. RESULTS : Despite identical prevailing insulin concentrations, glucose excursions 30 min postchallenge (but not later) were greater in women with abdominal obesity than in those without (162 ± 19 vs. 132 ± 16 mg/dl; P < 0.01). There was a strong correlation between hepatic glucose production suppression under low-dose insulin infusion and early-phase glucose excursions from the oral glucose tolerance test (r = -0.83; P < 0.001) in women with abdominal obesity, but not in women without (r = 0.44; P < 0.11). CONCLUSIONS : Abdominal obesity relates specifically to early-phase hyperglycemia via hepatic insulin resistance, even in healthy older women.

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