Preservation of ß-Cell Function in Autoantibody-Positive Youth With Diabetes  

Oleh:

Greenbaum, Carla J. ; Anderson, Andrea M. ; Dolan, Lawrence M. ; Mayer-Davis, Elizabeth J. ; Dabelea, Dana

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 32 no. 10 (Oct. 2009), page 1839-1844.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE To determine the extent of ß-cell function in youth with diabetes and GAD65 and/or IA2 autoantibodies. RESEARCH DESIGN AND METHODS Fasting C-peptide levels from 2,789 GAD65- and/or IA2 autoantibody-positive youth aged 1–23 years from the SEARCH for Diabetes in Youth study were used. Preserved ß-cell function was defined on the basis of cut points derived from the Diabetes Control and Complications Trial (DCCT) (fasting C-peptide =0.23 ng/ml) and from the U.S. adolescent population of the National Health and Nutrition Examination Survey (NHANES) 5th percentile for fasting C-peptide (=1.0 ng/ml). We compared the clinical characteristics between those with and without preserved ß-cell function. RESULTS Within the first year of diagnosis, 82.9% of youth had a fasting C-peptide =0.23 ng/ml and 31.2% had values =1.0 ng/ml. Among those with =5 years of diabetes duration, 10.7% had preserved ß-cell function based on the DCCT cutoff and 1.0% were above the 5th percentile of the NHANES population. CONCLUSIONS Within the 1st year of diagnosis, four of five youth with autoantibody-positive diabetes have clinically significant amounts of residual ß-cell function and about one-third have fasting C-peptide levels above the 5th percentile of a healthy adolescent population. Even 5 years after diagnosis, 1 of 10 has fasting C-peptide above a clinically significant threshold. These findings have implications for clinical classification of youth with diabetes as well as clinical trials aimed to preserve ß-cell function after diabetes onset.

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