T-cell-based Therapies for Malignancy and Infection in Childhood  

Oleh:

Ahmed, Nabil ; Heslop, Helen E. ; Mackall, Crystal L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 57 no. 01 (Feb. 2010), page 83-96.
Topik: Hematopoietic stem cell transplantation; Pediatrics; Adoptive immunotherapy; Tumor vaccines; Tumor antigens; Lymphopenia; Immune reconstitution; Chimeric antigen receptor

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

One major advance in T-cell–based immunotherapy in the last 20 years has been the molecular definition of numerous viral and tumor antigens. Adoptive T-cell transfer has shown definite clinical benefit in the prophylaxis and treatment of viral infections that develop in pediatric patients after allogeneic transplant and in posttransplant lymphoproliferative disease associated with the Epstein-Barr virus. Developing adoptive T-cell therapies for other malignancies presents additional challenges. This article describes the recent advances in T-cell–based therapies for malignancy and infection in childhood and strategies to enhance the effector functions of T cells and optimize the cellular product, including gene modification and modulation of the host environment.

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