Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor ? C-2821T and Diabetes on the Risk of Ischemic Stroke  

Oleh:

Fang-I, Hsieh ; Wei-Cheng, Lo ; Huey-Juan, Lin ; Yi-Chen, Hsieh

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 32 no. 11 (Nov. 2009), page 2033-2035.
Topik: STROKE; DIABETES; DIABETES MELLITUS; genetic polymorphisms of PPAR?; Ischemic stroke

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE : To explore the relationship between the genetic polymorphisms of PPAR? (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPAR? would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS : The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPAR? were determined by PCR–restriction fragment–length polymorphism. RESULTS : A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors. CONCLUSIONS : The -2821C allele of PPAR? was a strong predictor of ischemic stroke for diabetic patients.

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