Effects of n–3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus  

Oleh:

Stirban, Alin ; Nandrean, Simona ; Gotting, Christian ; Tamler, Ronald ; Pop, Alexandra ; Negrean, Monica ; Gawlowski, Thomas ; Stratmann, Bernd ; Tschoepe, Diethelm

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 91 no. 03 (Mar. 2010), page 808-813.
Topik: HEALTH AND NUTRITION

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: Recent evidence supports the protective effects of n–3 (omega-3) fatty acids (n–3 FAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on vascular function. Objective: We investigated the effects of EPA and DHA on postprandial vascular function in subjects with type 2 diabetes mellitus. Design: In a double-blind, placebo-controlled, randomized, crossover manner, 34 subjects with type 2 diabetes mellitus received daily either 2 g purified EPA/DHA (termed n–3 FAs) or olive oil (placebo) for 6 wk. At the end of this period, we measured macrovascular (brachial ultrasound of flow-mediated dilatation; FMD) and microvascular [laser-Doppler measurements of reactive hyperemia (RH) of the hand] function at fasting and 2, 4, and 6 h after a high-fat meal (600 kcal, 21 g protein, 41 g carbohydrates, 40 g fat). Results: Fasting vascular function remained unchanged after n–3 FAs and placebo. Postprandial FMD decreased from fasting after placebo, with a maximum decrease (38%) at 4 h—an effect that was significantly reduced (P = 0.03 for time x treatment interaction) by n–3 FA supplementation (maximum decrease in FMD was at 4 h: 13%). RH remained unchanged after placebo, whereas it improved significantly (P = 0.04 for time x treatment interaction) after n–3 FA supplementation (maximum increase was at 2 h: 27%). Conclusions: In subjects with type 2 diabetes mellitus, 6 wk of supplementation with n–3 FAs reduced the postprandial decrease in macrovascular function relative to placebo. Moreover, n–3 FA supplementation improved postprandial microvascular function. These observations suggest a protective vascular effect of n–3 FAs.

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