A dynamic assessment of sperm DNA fragmentation versus sperm viability in proven fertile human donors  

Oleh:

Gosalvez, Jaime ; Cortes-Gutierrez, Elva I ; Nunez, Rocio ; Fernandez, Jose Luis ; Caballero, Pedro

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 06 (Dec. 2009), page 1915-1919.
Topik: Andrology; sperm DNA fragmentation; sperm viability; fertility

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To analyze any possible dynamic correlation between sperm DNA fragmentation and sperm viability. Design The rate of viability loss and the rate of increase of the frequency of sperm cells with fragmented DNA were determined at 0, 1.5, 4.5, and 24.0 hours after thawing samples from donors with proven fertility. Setting Academic biology and reproductive medicine centers. Patient(s) Fifteen male donors with proven fertility for a maximum of six births at the reproductive medicine center. Intervention(s) None. Main Outcome Measure(s) Sperm DNA fragmentation and viability dynamics expressed as logarithmic coefficients of change. Result(s) The dynamics of sperm DNA fragmentation and sperm viability adjusted to a logarithmic function with an initial highest velocity that progressively decreases. Nevertheless, the rates were not statistically significantly correlated. Conclusion(s) In the short term, dynamic dysfunction of membrane permeability does not result in DNA fragmentation and thus must be considered as independent parameters of sperm quality.

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