Second-Trimester Amniotic Fluid Proinflammatory Cytokine Levels in Normal and Overweight Women  

Oleh:

Bugatto, Fernando ; Fernandez-Deudero, Alvaro

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Obstetrics and Gynecology vol. 115 no. 01 (Jan. 2010), page 127-133.
Topik: OBSTETRI GINEKOLOGI

Ketersediaan

Perpustakaan FK Nomor Panggil: O01.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE: To estimate the relationship between different adipokines and proinflammatory mediators in amniotic fluid and maternal body mass index (BMI), calculated as weight (kg)/height (m)2. METHODS: Seventy pregnant women who underwent amniocentesis for clinical reasons at 15–20 weeks of gestation were divided into two groups according to their BMI: a control group with normal weight (BMI 20–24.9, n=35) and a case group (BMI 25 or higher, n=35). The two groups were further divided into two subgroups: overweight (BMI 25–29.9, n=22) or obese (BMI 30 or more, n=13). Comparisons of amniotic fluid cytokines (tumor necrosis factor [TNF]-a, interleukin [IL]-8, IL-10, monocyte chemoattractant protein-1, resistin, and leptin) and C-reactive protein (CRP) levels were performed. The relationships between variables and maternal BMI were also analyzed. RESULTS: There were significant differences in amniotic fluid CRP and TNF-a levels among the studied groups: CRP, 0.018 (±0.010), 0.019 (±0.013), and 0.035 (±0.028) mg/dL (P=.007); and TNF-a, 3.98 (±1.63), 3.53 (±1.38), and 5.46 (±1.69) pg/mL (P=.003), for lean, overweight, and obese women, respectively. Both proinflammatory mediators increased in women with obesity compared with both overweight and normal women (P=.01 and P=.008 for CRP; P=.003 and P=.01 for TNF-a, respectively). There were significant correlations between maternal BMI and amniotic fluid CRP (r=0.396; P=.001), TNF-a (r=0.357; P=.003) and resistin (r=0.353; P=.003). CONCLUSION: Amniotic fluid CRP and TNF-a levels are increased in obese women, and both are related to maternal BMI, which suggests in utero exposure to higher proinflammatory cytokines and mediators in fetuses of these women.

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