Results with early follicular phase recombinant luteinizing hormone supplementation during stimulation for in vitro fertilization  

Oleh:

Kovacs, Peter ; Kovats, Timea ; Kaali, Steven G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 02 (Jan. 2010), page 475-479 .
Topik: OBSTETRI GINEKOLOGI; Recombinant LH; IVF; ovarian stimulation; pregnancy rate; expense

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: To study the effect of early follicular phase recombinant LH supplementation on stimulation outcome among women undergoing IVF using the GnRHa long protocol and recombinant FSH. Design: Randomized, controlled trial. Setting: Private IVF unit. Patient(s): Women under the age of 40 with normal ovarian function undergoing their first or second IVF cycle. Intervention(s): All stimulations followed the standard luteal long GnRHa down-regulation protocol. At suppression, patients in the experimental group received 75 IU of rLH daily for 4 days, and recombinant FSH at a fixed starting dose of 150 IU for the first 5 days was started a day later, on day 2 of rLH. In the control group, patients started rFSH at a fixed dose of 150 IU for the first 5 days at suppression. Main Outcome Measure(s) Baseline, stimulation, embryology parameters, and treatment outcome were compared. Of primary interest, recombinant FSH need during stimulation was assessed. Result(s): Stimulation, embryology parameters, and treatment outcome were comparable. The amount of gonadotropins used and medication expense were similar in the two groups. Conclusion(s): Early follicular phase recombinant LH supplementation at a daily dose of 75 IU does not improve response to stimulation among normal responder women undergoing IVF.

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