Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration-dependent manner  

Oleh:

Bo, Sun Joo ; Sea, Hee Park ; Byeong, Min An

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 93 no. 02 (Jan. 2010), page 442-446 .
Topik: OBSTETRI GINEKOLOGI; IVF-ET; controlled ovarian hyperstimulation; serum E2 levels; pregnancy outcome

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To determine an optimal serum E2 level on the day of hCG administration in controlled ovarian hyperstimulation (COH) during IVF-ET without compromising pregnancy outcome. Design: Retrospective study. Setting Large urban medical center. Patient(s) Data of 455 cycles of fresh IVF-ET with COH. Intervention(s) Serum E2 levels on the day of hCG administration were categorized into five groups: group A (<1000 pg/mL), group B (1000–2000 pg/mL), group C (2000–3000 pg/mL), group D (3000–4000 pg/mL), and group E (>4000 pg/mL). Main Outcome Measure(s) Serum E2 levels, number of oocytes retrieved, pregnancy outcomes. Result(s) Of 455 cycles, 148 (32.5%) cycles resulted in clinical pregnancy. The implantation rate was 12.2%, and the delivery rate was 18.7%. The number of oocytes obtained increased with increasing serum E2 levels. The pregnancy rate gradually increased from group A to D as E2 levels increased but decreased in group E. In women <38 years, the IVF-ET outcomes were similar to those of total patients. However, in women =38 years old, pregnancy and delivery rates were higher in group C than in other groups. Conclusion(s) These results show that serum E2 levels have a concentration-dependent effect on the pregnancy outcome, suggesting an optimal range of E2 level for achieving a successful pregnancy. This optimal range of serum E2 level in women is age dependent: 3000–4000 pg/mL for women <38 years and 2000–3000 pg/mL for women =38 years.

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